Home Betting Picks NFL Best Match of the Day: San Francisco 49ers vs Arizona Cardinals

NFL Best Match of the Day: San Francisco 49ers vs Arizona Cardinals

San Francisco 49ers vs Arizona Cardinals Predictions


Key Stat: 49ers have won two games in a row

Tip Reasoning

  • Arizona is 4-6 on the season
  • San Francisco is 5-4 on the year
  • The 49ers are averaging 22 points per game


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The NFL week is coming to a close, but there is one more game left, and it’s the Monday Night tilt between the San Francisco 49ers and Arizona Cardinals. This is one of the NFL’s international games, so instead of it being played in Arizona, it’ll be held in Mexico City. The 49ers have won two in a row and are trying to catch the Seattle Seahawks for first in the NFC West Division.

The Niners have seen their offensive production increase since the trade for Christian McCaffery, and they’ll look to continue it against a Cardinals defense that’s allowing 23 points per game. The Cardinals have had a disappointing season but managed to beat the Rams last week and are looking for two wins in a row. Kyler Murray and the Arizona offense are looking to find some consistency with the wide receivers, but they’ll be without Marquise Brown, but may have DeAndre Hopkins available. The Niners are favored by 8 points, but we think Arizona will keep it close. We’ll take the Cardinals to cover the +8 point spread against San Francisco.

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Tip Reasoning

Key Stat: San Francisco only allows 18 points per game

  • The Niners only give up 82 rushing yards per game
  • Arizona is giving up 354 yards per game on defense
  • The Cardinals are averaging 23 points per game on offense

The next line we’ll look at for the 49ers-Cardinals game is the Over/Under of 43 points. This game is cautiously favored toward more of a defensive struggle, even though the San Francisco offense has been getting better. While Arizona has star power on the offensive side of the ball, they haven’t been able to stay healthy or muster much of a running attack, which has left them unbalanced offensively. This San Francisco defense may be the best in football and they should contain the Cardinals on Monday night. We’ll take Under 43 points for the Niners-Cardinals game.

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Patrick Culhane
Father of two beautiful kids. Grew up around sports, still waiting for the Vikings to win the Super Bowl. Is very adamant that Breaking Bad is the best tv show ever.