New York Giants vs San Francisco 49ers predictions

The New York Giants and the San Francisco 49ers face off, with the Giants seeking consecutive road wins and the 49ers aiming for a flawless start, as both teams showcase their strengths and weaknesses. Read on for our free match preview and betting picks.

NY Giants
Match Live Thursday 21th September, 8:15 PM ET
DAYS
Hr
Min
Sec
Key Stats
– The Giants have averaged 117.5 ground yards per game, with Saquon Barkley contributing 114 yards.
– The 49ers’ robust offense averages 173.5 yards every match, with Christian McCaffrey sprinting to 268 yards so far.
– In their last 16 games as massive underdogs, the Giants have covered the spread 12 times.
BettingPicks Expert Predictions

New York Giants +10.5 Win (-110)

★★★★★
BetMGM

Best Offer Of The Day

William hill


William hill


Gambling problem? Call 1-800-GAMBLER CO, DC, IL, IN, LA, MD, MS, NJ, OH, PA, TN, VA, WV, WY Call 877-8-HOPENY or text HOPENY (467369) (NY) Call 1-800-327-5050 (MA) 21+ to wager. Please Gamble Responsibly. Call 1-800-NEXT-STEP (AZ), 1-800-522-4700 (KS, NV), 1-800-BETS-OFF (IA), 1-800-270-7117 for confidential help (MI). Visit BetMGM.com for Terms & Conditions. US promotional offers not available in DC, Nevada, New York or Ontario.

New York Giants vs San Francisco 49ers predictions: A Detailed Preview

New York Giants: Road Warriors?

The New York Giants are on a quest. After a string of mixed results, splitting their last eight road ventures, they’re keen on securing consecutive away victories to rise above a 50% win rate. Daniel Jones, the quarterback, has managed to complete 63.1% of his passes, covering 425 yards with two touchdowns and three interceptions. When it comes to receivers, the duo of Darren Waller and Jalin Hyatt have chalked up 201 receiving yards from 11 catches. Not to be overshadowed, Darius Slayton has successfully pulled in 6 receptions.

On the ground, the Giants have averaged a respectable 117.5 yards per game. Saquon Barkley has been the star runner, accumulating 114 yards and bagging a touchdown. However, the defensive side tells a slightly more concerning tale. The Giants have conceded an average of 34 points and 322 yards per game. Jason Pinnock stands out on defense with a total of 18 tackles, closely followed by Micah McFadden with 16, and Xavier McKinney recording 3 pass deflections.

San Francisco 49ers: Seeking Perfection at Home

The San Francisco 49ers are hunting for a landmark. They’re eager to celebrate their maiden home victory of the season and maintain an unblemished record. It’s been a while since they’ve had such a promising start; they last began 3-0 in 2019, a year that saw them journeying to the Super Bowl. Quarterback Brock Purdy boasts a 66.7% pass completion rate, racking up 426 yards, two touchdowns, and importantly, no interceptions. Receivers Brandon Aiyuk and Deebo Samuel are a force to be reckoned with, together amassing 290 receiving yards and two touchdowns. Meanwhile, Jauan Jennings has made 2 significant catches.

On the turf, the 49ers have been particularly formidable, averaging a robust 173.5 yards every game. Christian McCaffrey is undoubtedly the linchpin, racing to 268 yards and registering two touchdowns. The team’s defense is considerably stingier than the Giants’, letting in just 15 points and 312.5 yards on an average match. Fred Warner is the standout, with 19 tackles to his name, while Drake Jackson and Charvarius Ward have recorded 3 sacks and an interception respectively.

Predictions and Picks

At first glance, the San Francisco 49ers seem poised to dominate, even potentially securing a runaway victory. Just last week, after a significant deficit against the Cardinals, the Giants were prematurely dubbed as possibly the weakest team. However, they managed a comeback, illustrating their unpredictability. But here’s the twist. Considering it’s a short week, betting on a team with just a few preparation days might be risky. It’s noteworthy that the Giants have a track record of covering in 12 of their last 16 games when they’re massive underdogs. Betting enthusiasts might just want to consider those odds.

BettingPicks Expert Predictions

New York Giants +10.5 Win (-110)

★★★★★
BetMGM

Top US Sportsbooks & Best Sign Up Offers 

SPORTSBOOK

RATING & HOW TO CLAIM THE OFFER

  • Register & Deposit

  • Place 1st Bet 

  • Get up to $1,500 paid back in Bonus Bets if you don’t win

Gambling problem? Call 1-800-GAMBLER
CO, DC, IL, IN, LA, MD, MS, NJ, OH, PA, TN, VA, WV, WY, MA
Call 877-8-HOPENY or text HOPENY (467369) (NY)
Call 1-800-327-5050 (MA)
21+ to wager. Please Gamble Responsibly. Call 1-800-NEXT-STEP (AZ), 1-800-522-4700 (KS, NV), 1-800-BETS-OFF (IA), 1-800-270-7117 for confidential help (MI). 
Visit BetMGM.com for Terms & Conditions. US promotional offers not available in DC, Nevada, New York, KS, MS or Ontario.

Pick

How to Claim?

Simply Click Below To Claim The Offer

  • Register & Deposit

  • Place 1st Bet 

  • Get up to five second chance bets for $100 each

New User Bonus. 21+; Valid Only In Selected States; T&Cs Apply.

Pick

How to Claim?

Simply Click Below To Claim The Offer

New Jersey/Colorado/Virginia users:

  • Register for a new bet365 account

  • Place a qualifying bet of $1

  • Get $200 in Bonus bets - no matter if your bet wins or loses

21+; New Customers only. Bet $1 and Get $200 in Bonus Bets at bet365.
Deposit required. Bonus Bets winnings are added to Bonus Bets balance. Bonus Bet wager excluded from returns. T&Cs, time limits and exclusions apply. NJ/VA: Gambling Problem? Call 1-800-Gambler 21+ / CO: Gambling Problem? Call or TEXT 1-800-Gambler 21+

Pick

How to Claim?

NJ/CO/VA users -> Simply Click Below To Claim The Offer

Ohio users:

  • Register for a new bet365 account

  • Place a qualifying bet of $1

  • Get $200 in Bonus bets - no matter if your bet wins or loses

21+; New Customers only. Bet $1 and Get $200 in Bonus Bets at bet365.
Deposit required. Bonus Bets winnings are added to Bonus Bets balance. Bonus Bet wager excluded from returns. T&Cs, time limits and exclusions apply. Gambling Problem? Call 1-800-522-4700
21+, must be physically located in OH. Terms and Conditions Apply

Pick

How to Claim?

Ohio users -> Simply Click Below To Claim The Offer

  • If your first cash bet loses, you’ll get it back as a Bonus Bet – up to $1,000

  • Use Promo Code: SB4Y1000

New User Bonus. 21+; Valid Only In Selected States; T&Cs Apply.

Pick

How to Claim?

Click on the button related to your state to claim Caesars offer 

  • Up To $500 2nd Chance Bet

  • Use Promo Code: SPORTS

  • Regular Promotions

New User Bonus. 21+; Valid Only In Selected States; T&Cs Apply.

Pick

How to Claim?

Click on the button related to your state to claim BetRivers offer 

  • Exclusive Offer

  • Great Live Betting Section

  • $100 Risk Free Bet

New User Bonus. 21+; Valid Only In Selected States; T&Cs Apply.

Pick

How to Claim?

Click on the button related to your state to claim Unibet offer 

Subscribe Free – Exclusive Picks In Your Inbox

Want to have exclusive tips from experts tipsters delivered right into your inbox? Subscribe Now To Our Newsletter. We will never spam, we fully respect your privacy!

Previous articleNC State Wolfpack vs Virginia Cavaliers Predictions
Next articleMLB Prop Bets Today!
Carl Tarver
Born and raised in Denver and a former college baseball player, I'm an avid fan of prop bets, especially on the NBA, NHL, NFL, and NCAA. looking to find an edge by any means necessary. As a lifelong Nuggets fan, I promise to be very impartial when the Nuggets are not involved!